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PGF 2 derivatives are accustomed to medically lower IOP by affecting the FP receptor. These include latanoprost (Xalatan), travoprost (Travatan), bimatoprost (Lumigan) and unoprostone isopropyl (Rescula). Forskolin (Colforsin) works upon the complementary IOP-lowering but anti-inflammatory PGE 2 pathway using the c-AMP-mediated EP 2, EP 3 and EP 4 receptors.
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