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PGF 2 derivatives are widely-used to medically lower IOP by affecting the FP receptor. These include latanoprost (Xalatan), travoprost (Travatan), bimatoprost (Lumigan) and unoprostone isopropyl (Rescula). Forskolin (Colforsin) works on the complementary IOP-lowering but anti-inflammatory PGE 2 pathway from the c-AMP-mediated EP 2, EP 3 and EP 4 receptors.
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Forskolin is considered to be recognized to achieve qualities that will help in curing heart conditions, asthma, glaucoma, insomnia, allergy symptoms, skin issues, irritable bowel syndrome, bladder problems, and even sexual dysfunction among men or women. Its main task is directed towards heart muscles because this efficient cure to problems related on the heart.
Regulating intra-cellular communication via prostaglandins has demonstrated superior diurnal IOP therapy for all other glaucoma pharmaceuticals. Coleus forskohlii also regulates intra-cellular communication via c-AMP which mediates most in the effects of prostaglandin PGE 2 (see chart).
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