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A study of 113 patients with chronic simple glaucoma showed immediate IOP increases up to 20 mm Hg upon challenge (exposure) with food or other allergens. Another study of 3 individual cases of simple glaucoma, revealed that elimination of food allergens markedly improved treatment outcomes compared to treatment with drugs and surgery or drugs solely. In one case, intraocular pressure could only be controlled once allergens were eliminated for this diet. In 2 other cases, despite adequate control of IOP having a combination of drugs and surgery, visual field loss continued to progress. Visual fields actually improved markedly upon beginning an allergen-free diet. Sjogren was extremely first to identify the relationship between allergy and IOP.
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